Epigallocatechin-3-gallate protects bovine ruminal epithelial cells against lipopolysaccharide-induced inflammatory damage by activating autophagy
Subacute ruminal acidosis causes ruminal epithelium injury and systemic inflammation in dairy cows. However, the anti-inflammatory effects of EGCG help preserve the integrity of the epithelial barrier through activating autophagy when BREC are exposed to LPS. Thus, EGCG could potentially serve as an effective therapeutic agent for SARA-associated inflammation.
Authors
- Zhaoju Deng (ORCID: https://orcid.org/0000-0002-9297-7956)
- Ben Aernouts (ORCID: https://orcid.org/0000-0001-6266-3019)
- Bi-Chen Zhao
- Yihui Huo
- Juan J. Loor (ORCID: https://orcid.org/0000-0003-1586-4365)
- Androniki Psifidi (ORCID: https://orcid.org/0000-0003-4095-1452)
- Moli Li
- Wanli Zhao
- Chuang Xu
Institutions
- Royal Veterinary College (GB)
- University of Illinois Urbana-Champaign (US)
- China Agricultural University (CN)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2024-08-08
- DOI
- https://doi.org/10.1186/s40104-024-01066-9
- Citations
- 7
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 1.68