Borane‐Catalyzed Asymmetric Reduction of 2‐Alkylpyridines<sup>†</sup>
Comprehensive Summary Herein, a method for the enantioselective reduction of unprotected 2‐alkylpyridines is reported for the first time. By using pinacolborane and an amide as reducing agents, a large number of 2‐alkylpiperidines were synthesized with high yields and excellent enantioselectivities via a cascade process involving 1,4‐hydroboration and subsequent transfer hydrogenation. The resulting products can be easily converted to natural alkaloids.
Authors
- Heng Luo (ORCID: https://orcid.org/0000-0001-5192-8878)
- Zhao‐Ying Yang
- Xiaochen Wang (ORCID: https://orcid.org/0000-0001-5863-0804)
- Ming Zhang (ORCID: https://orcid.org/0000-0002-1800-9041)
Institutions
- Nankai University (CN)
- Unité Matériaux et Transformations (FR)
Publication Details
- Journal
- Chinese Journal of Chemistry
- Published
- 2024-08-08
- DOI
- https://doi.org/10.1002/cjoc.202400671
- Citations
- 4
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.63
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City
- National Key Research and Development Program of China