Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19

We investigated the effects of 35 inflammatory cytokines on respiratory outcomes, including COVID-19, asthma (atopic and non-atopic), chronic obstructive pulmonary disease (COPD), and pulmonary function indices, using Mendelian randomization and colocalization analyses. The emerging associations were further explored using observational analyses in the UK Biobank. We found an inverse association between genetically predicted macrophage colony stimulating factor (MCSF), soluble intercellular adhesion molecule-1 (sICAM), and soluble vascular cell adhesion molecule-1 with risk of COVID-19 outcomes. sICAM was positively associated with atopic asthma risk, whereas tumor necrosis factor-alfa showed an inverse association. A positive association was shown between interleukin-18 and COPD risk (replicated in observational analysis), whereas an inverse association was shown for interleukin-1 receptor antagonist (IL-1ra). IL-1ra and monocyte chemotactic protein-3 were positively associated with lung function indices, whereas inverse associations were shown for MCSF and interleukin-18 (replicated in observational analysis). Our results point to these cytokines as potential pharmacological targets for respiratory traits.

Authors

Institutions

Publication Details

Journal
iScience
Published
2024-08-08
DOI
https://doi.org/10.1016/j.isci.2024.110704
Citations
2
Primary Topic
Chronic Obstructive Pulmonary Disease (COPD) Research
Type
article
Field-Weighted Citation Impact
0.84

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19

James Yarmolinsky, Konstantinos K. Tsilidis, Ioanna Tzoulaki, Karl‐Heinz Herzig et al.
2 citations
iScience
Chronic Obstructive Pulmonary Disease (COPD) Research
0.84
article

Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19

James Yarmolinsky, Konstantinos K. Tsilidis, Ioanna Tzoulaki, Karl‐Heinz Herzig, Marina O. Rontogianni, Abril G. Izquierdo, Martin D. Tobin, Dipender Gill, Markku Timonen, Olli Tuomas Raitakari, Ville Karhunen, Veikko V Salomaa, Matthias Wielscher, Marjo‐Riitta Järvelin, Abbas Dehghan, Terho Lehtimäki, Emmanouil Bouras, Sirpa Jalkanen, Alexandros‐Georgios Asimakopoulos, Jing Chen, Anne E Ioannides, Marko Salmi
article en
2 citations

Abstract

We investigated the effects of 35 inflammatory cytokines on respiratory outcomes, including COVID-19, asthma (atopic and non-atopic), chronic obstructive pulmonary disease (COPD), and pulmonary function indices, using Mendelian randomization and colocalization analyses. The emerging associations were further explored using observational analyses in the UK Biobank. We found an inverse association between genetically predicted macrophage colony stimulating factor (MCSF), soluble intercellular adhesion molecule-1 (sICAM), and soluble vascular cell adhesion molecule-1 with risk of COVID-19 outcomes. sICAM was positively associated with atopic asthma risk, whereas tumor necrosis factor-alfa showed an inverse association. A positive association was shown between interleukin-18 and COPD risk (replicated in observational analysis), whereas an inverse association was shown for interleukin-1 receptor antagonist (IL-1ra). IL-1ra and monocyte chemotactic protein-3 were positively associated with lung function indices, whereas inverse associations were shown for MCSF and interleukin-18 (replicated in observational analysis). Our results point to these cytokines as potential pharmacological targets for respiratory traits.

iScienceVol. 27(10)
Poznan University of Medical Sciences (PL), Tampere University of Applied Sciences (FI), University of Leicester (GB), University of Turku (FI), Turku University of Applied Sciences (FI), University of Ioannina (GR), Oulu University Hospital (FI), Turku University Hospital (FI), Glenfield Hospital (GB), Public Health England (GB), National Institute for Health and Care Research (GB), University of Bristol (GB), Finnish Institute for Health and Welfare (FI), University of Oxford (GB), UK Dementia Research Institute (GB), Tampere University (FI), Fimlab (Finland) (FI), MRC Epidemiology Unit (GB), Imperial College London (GB), Brunel University of London (GB), University of Oulu (FI)
Foundation for Cardiovascular Research, Joint Programming Initiative A healthy diet for a healthy life, European Commission, Kela, Suomen Kulttuurirahasto, Juho Vainion Säätiö, Signe ja Ane Gyllenbergin Säätiö, Emil Aaltosen Säätiö, Socialdepartementet, Sydäntutkimussäätiö, Oulun Yliopisto, Tampereen Tuberkuloosisäätiö, Diabetesliitto, Paavo Nurmen Säätiö, Tays, Syöpäsäätiö, Terveyden ja hyvinvoinnin laitos, Horizon 2020 Framework Programme, Medical Research Council, Biotechnology and Biological Sciences Research Council, European Regional Development Fund
Good health and well-being
Openalex Percentile: Top 25%
Chronic Obstructive Pulmonary Disease (COPD) Research
0.84
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.