Macrophage OTUD1‐CARD9 axis drives isoproterenol‐induced inflammatory heart remodelling
Macrophage CARD9 was elevated in heart tissues of mice under chronic ISO administration. Either whole-body CARD9 knockout or myeloid-specific CARD9 deficiency protected mice from ISO-induced inflammatory heart remodeling. ISO promoted the assembly of CBM complex and then activated NF-κB signaling in macrophages through OTUD1-mediated deubiquitinating modification. OTUD1 deletion in myeloid cells protected hearts from ISO-induced injuries in mice.
Authors
- Qinyan Wang (ORCID: https://orcid.org/0000-0002-4591-6616)
- Xiaohong Long
- Gaojun Wu (ORCID: https://orcid.org/0009-0007-7454-6312)
- Jiachen Xu
- Xiaocheng Guo (ORCID: https://orcid.org/0000-0003-0541-0597)
- Weijian Huang (ORCID: https://orcid.org/0000-0001-8417-7804)
- Guang Liang (ORCID: https://orcid.org/0000-0002-8278-849X)
- Yi Wang (ORCID: https://orcid.org/0000-0002-4954-6317)
- Qingsong Zheng
- Jinfu Qian (ORCID: https://orcid.org/0000-0002-0508-9097)
- Julian Min
- Shiqi Liang (ORCID: https://orcid.org/0000-0001-8434-406X)
- Wu Luo (ORCID: https://orcid.org/0000-0001-7383-9470)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/ctm2.1790
- Citations
- 19
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 7.64
Funders
- National Natural Science Foundation of China