Single‐cell sequencing combined with spatial transcriptomics reveals that the IRF7 gene in M1 macrophages inhibits the occurrence of pancreatic cancer by regulating lipid metabolism‐related mechanisms
Overexpression of IRF7 in M1 macrophages may inhibit RPS18 transcription, reduce the transfer of RPS18 from M1 macrophage-derived exosomes to PAAD cells, thereby suppressing ILF3 expression in PAAD cells, inhibiting the lipid metabolism pathway, and curtailing the viability, proliferation, migration, invasion of PAAD cells, as well as enhancing cell apoptosis, ultimately inhibiting tumour formation in PAAD cells in vivo. Targeting IRF7/RPS18 in M1 macrophages could represent a promising immunotherapeutic approach for PAAD in the future.
Authors
- Yanli Zou (ORCID: https://orcid.org/0000-0001-5793-8065)
- Ting Zhan (ORCID: https://orcid.org/0000-0003-0622-7890)
- Qingxi Zhu (ORCID: https://orcid.org/0000-0001-7154-9939)
- Mengge Chen
- Mingtao Chen (ORCID: https://orcid.org/0000-0001-5110-0835)
- Meng Liu (ORCID: https://orcid.org/0000-0001-9920-5599)
- Weijie Liu (ORCID: https://orcid.org/0000-0002-8023-9913)
- Jie Tan (ORCID: https://orcid.org/0000-0002-0909-2904)
- Zheng Han (ORCID: https://orcid.org/0000-0003-1537-3822)
- Jiaxi Liu (ORCID: https://orcid.org/0000-0003-2140-9000)
- Wei Chen (ORCID: https://orcid.org/0000-0002-9934-4000)
- Xiaodong Huang (ORCID: https://orcid.org/0000-0002-5815-7655)
- Xiao-Rong Tian
- Xiulin Yang
Institutions
- Wuhan University (CN)
- Tongren Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Wuhan Third Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/ctm2.1799
- Citations
- 17
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.09