Association of pre-existing cardiovascular disease with administration of fluoropyrimidine chemotherapy in patients with gastrointestinal malignancies
GI cancer patients with all types of pre-existing CVD are less likely to receive fluoropyrimidine chemotherapy despite eligibility. This suggests widespread caution regarding administration of fluoropyrimidines across this population; further research is needed to assess whether such conservatism is justified.
Authors
- Pinkie Chambers (ORCID: https://orcid.org/0000-0002-6669-9411)
- Paul C. Lambert (ORCID: https://orcid.org/0000-0002-5337-663X)
- Sally Vernon (ORCID: https://orcid.org/0009-0007-6290-715X)
- Mark J. Rutherford (ORCID: https://orcid.org/0000-0003-1557-6697)
- Catherine Welch (ORCID: https://orcid.org/0000-0002-6687-964X)
- Kai‐Keen Shiu (ORCID: https://orcid.org/0000-0001-6202-9640)
- Chengsheng Ju (ORCID: https://orcid.org/0000-0001-7860-6262)
- Aderonke Abiodun (ORCID: https://orcid.org/0000-0002-2304-3551)
- Charlotte Manisty (ORCID: https://orcid.org/0000-0003-0245-7090)
- Lizz Paley (ORCID: https://orcid.org/0000-0002-3879-5377)
- Mark de Belder (ORCID: https://orcid.org/0000-0003-2690-8319)
- David Adlam (ORCID: https://orcid.org/0000-0002-0080-9884)
- Jennifer Lai (ORCID: https://orcid.org/0000-0002-0593-1424)
- Freya Tyrer (ORCID: https://orcid.org/0000-0003-2877-4342)
- Li Wei (ORCID: https://orcid.org/0000-0001-8840-7267)
- John Deanfield
- Sarah Slater
- Michael Peake
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- University of Leicester (GB)
- Barts Health NHS Trust (GB)
- Glenfield Hospital (GB)
- Karolinska Institutet (SE)
- Cancer Research UK Oxford Centre (GB)
- NIHR Research Delivery Network (GB)
- NIHR Leicester Biomedical Research Centre (GB)
- NHS England
- University College London (GB)
Publication Details
- Journal
- BMJ Oncology
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1136/bmjonc-2024-000323
- Citations
- 1
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Cancer Research UK
- National Institute for Health and Care Research
- British Heart Foundation
- University College London
- Barts Health NHS Trust