PTSD moderates the association between subjective cognitive decline and Alzheimer’s disease biomarkers in older veterans
Higher SCD was associated with greater tau and amyloid burden and worse cognitive performance across the sample, though the tau and amyloid associations were stronger for Veterans without PTSD. Results highlight the potential benefit of comprehensive clinical assessments including consideration of mental health among older Veterans with SCD to understand the underlying cause of the cognitive concerns. Additionally, more work is needed to understand alternative mechanisms driving SCD in older Veterans with PTSD.
Authors
- Victoria C. Merritt (ORCID: https://orcid.org/0000-0001-5683-4168)
- Alexandra J. Weigand (ORCID: https://orcid.org/0000-0002-7931-1383)
- Alexandra L. Clark (ORCID: https://orcid.org/0000-0002-7437-5409)
- Kelsey R. Thomas (ORCID: https://orcid.org/0000-0003-4277-8876)
- Peter Rantins
- Uriel Urias
- Mary Ellen García
- Katherine J. Bangen
- Britney Luu
Institutions
- San Diego State University (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Aging & Mental Health
- Published
- 2024-08-08
- DOI
- https://doi.org/10.1080/13607863.2024.2389547
- Citations
- 2
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Merck
- Roche
- Medpace
- BioClinica
- Novartis Pharmaceuticals Corporation
- Takeda Pharmaceutical Company
- Northern California Institute for Research and Education
- Servier
- IXICO
- National Institutes of Health
- Genentech
- GE Healthcare
- University of California, San Diego
- Canadian Institutes of Health Research
- Eisai Incorporated
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering