Analysis of the Role of D-Dimer, Interleukin-6, and Interleukin-18 in Differential Diagnosis of Pediatric Refractory Mycoplasma pneumoniae Pneumonia

Objective: To analyze the value of D-dimer (D-D), interleukin-6 (IL-6), and IL-18 in the differential diagnosis of children with refractory Mycoplasma pneumoniae pneumonia (RMPP). Methods: The medical records of 92 children with Mycoplasma pneumoniae pneumonia (MPP) treated in the hospital were selected for retrospective analysis from January 2023 to January 2024. After comprehensive examinations such as computed tomography examination of the chest, 48 children with general Mycoplasma pneumoniae pneumonia (GMPP) were put in the GMPP group and 44 children with RMPP were grouped in the RMPP group. The IL-6, IL-18, and D-D levels were compared between the two groups, and the receiver operating characteristic (ROC) curves were plotted to analyze their value for differential diagnosis of RMPP. Results: The levels of IL-6, IL-18, and D-D in the RMPP group were higher than those in the GMPP group (P < 0.05); the ROC curves showed that the specificity of the differential diagnosis of IL-6, IL-18, and D-D was higher, and their diagnostic value was significant. Conclusion: Determination of IL-6, IL-18, and D-D levels in children with MPP can further diagnose the children’s condition, which can help physicians formulate targeted treatment plans, and is of great significance to the improvement of the children’s condition, which is worthy of attention.