Novel Genetic Loci in Early‐Onset Gout Derived From Whole‐Genome Sequencing of an Adolescent Gout Cohort
This is the first comprehensive genetic characterization of adolescent-onset gout. The identified risk loci of early-onset gout mediate inflammatory responsiveness to crystals that could mediate gouty arthritis. This study will contribute to risk prediction and therapeutic interventions to prevent adolescent-onset gout.
Authors
- Wenrui Shi (ORCID: https://orcid.org/0000-0001-6125-0327)
- Yongyong Shi (ORCID: https://orcid.org/0000-0003-1710-1505)
- Tony Raymond Merriman (ORCID: https://orcid.org/0000-0003-0844-8726)
- Jingfa Xiao (ORCID: https://orcid.org/0000-0002-2835-4340)
- Changqing Zeng
- Yuwei He (ORCID: https://orcid.org/0000-0002-5107-5323)
- Yue Liang (ORCID: https://orcid.org/0000-0002-5925-6743)
- Xinde Li (ORCID: https://orcid.org/0000-0002-1529-4537)
- Aichang Ji
- Lei Pang (ORCID: https://orcid.org/0000-0002-2285-2728)
- Guangmin Zheng (ORCID: https://orcid.org/0000-0002-3781-170X)
- Xiulin Ji (ORCID: https://orcid.org/0000-0002-1752-6602)
- Fei Yan (ORCID: https://orcid.org/0000-0002-3381-1489)
- Riku Takei (ORCID: https://orcid.org/0000-0002-1243-2535)
- Yushuang Li (ORCID: https://orcid.org/0000-0002-2002-7353)
- Xiaomei Xue (ORCID: https://orcid.org/0000-0002-1430-0130)
- Can Wang (ORCID: https://orcid.org/0009-0009-8617-483X)
- Jie Lü (ORCID: https://orcid.org/0000-0003-2886-8285)
- Lingling Cui (ORCID: https://orcid.org/0000-0003-1367-5851)
- Maichao Li
- Zhanjie Fang (ORCID: https://orcid.org/0000-0003-3718-3747)
- Wenyan Sun (ORCID: https://orcid.org/0000-0003-2265-3566)
- Han Qi (ORCID: https://orcid.org/0000-0002-0720-2305)
- Hongzhu Qu (ORCID: https://orcid.org/0000-0001-7013-8409)
- Robert Terkeltaub (ORCID: https://orcid.org/0000-0001-5368-7473)
- Nicola Dalbeth (ORCID: https://orcid.org/0000-0003-4632-4476)
- Mingshu Sun (ORCID: https://orcid.org/0000-0001-9671-5323)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-8791-5753)
- Zhiqiang Li (ORCID: https://orcid.org/0000-0002-0174-9254)
- Jiayi Wang (ORCID: https://orcid.org/0000-0003-1688-2864)
- Xuefeng Wang (ORCID: https://orcid.org/0000-0002-9361-0398)
- Changgui Li (ORCID: https://orcid.org/0000-0002-4622-3731)
- Lin Han (ORCID: https://orcid.org/0000-0002-0237-2364)
- Cheng Zan
- Zhen Liu
- Xiangdong Fang (ORCID: https://orcid.org/0000-0002-6628-8620)
- Yang Sui
Institutions
- Qingdao University (CN)
- University of Auckland (NZ)
- Chinese Academy of Sciences (CN)
- Beijing Institute of Genomics (CN)
- University of Alabama at Birmingham (US)
- University of California San Diego (US)
- Affiliated Hospital of Qingdao University (CN)
- Shanghai Center For Bioinformation Technology (CN)
- University of Chinese Academy of Sciences (CN)
- University of Otago (NZ)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1002/art.42969
- Citations
- 9
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 3.05
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China