AMPK Activation in TET2 Downregulated Leukemia Cells Upon Glutamine Limitation

Our findings indicate that TET2-knockdown HL-60 cells may be more resistant to glutamine deprivation. In glutamine-deficient medium, the mRNA expression of glutamine synthetase is increased, which could be related to glutamine addiction in cells. In addition, low-glutamyl medium increased the P-AMPKα protein level in TET2-knockdown HL-60 cells.

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Journal
Medeniyet Medical Journal
Published
2024-08-09
DOI
https://doi.org/10.4274/mmj.galenos.2024.59683
Primary Topic
Cancer, Hypoxia, and Metabolism
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article
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article

AMPK Activation in TET2 Downregulated Leukemia Cells Upon Glutamine Limitation

Burcu Yücel, Ahsen Merve BAYRAK
Medeniyet Medical Journal
Cancer, Hypoxia, and Metabolism
article

AMPK Activation in TET2 Downregulated Leukemia Cells Upon Glutamine Limitation

Burcu Yücel, Ahsen Merve BAYRAK
article en

Abstract

Our findings indicate that TET2-knockdown HL-60 cells may be more resistant to glutamine deprivation. In glutamine-deficient medium, the mRNA expression of glutamine synthetase is increased, which could be related to glutamine addiction in cells. In addition, low-glutamyl medium increased the P-AMPKα protein level in TET2-knockdown HL-60 cells.

Medeniyet Medical JournalVol. 39(3)
Istanbul Medeniyet University (TR)
Zero hunger
Openalex Percentile: Top 80%
Cancer, Hypoxia, and Metabolism
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AMPK Activation in TET2 Downregulated Leukemia Cells Upon Glutamine Limitation — Burcu Yücel, Ahsen Merve BAYRAK · Medeniyet Medical Journal (2024) | TGRS Research Map | TGRS