Molecular docking, derivatization, characterization and biological assays of amantadine
<b>Background:</b> Derivatization has been tremendously utilized in the field of drug discovery for optimizing the pharmacological properties and improving safety, efficacy and selectivity.<b>Methodology:</b> Schiff's bases (AD1-AD11) are synthesized through amantadine condensation with different aldehydes and ketones. Fourier transform infrared, <sup>1</sup>H NMR, <sup>13</sup>C NMR, TLC, liquid chromatography mass spectrometry analysis, <i>in silico</i> studies, molecular docking and antiviral activity through hemagglutinin test were performed for evaluation of new compounds.<b>Results:</b> AD2, 3 and 9-11 showed greater antiviral activity than the parent drug. Among all derivatives, AD2 and AD3 exhibited good potential against α-amylase while AD7 and AD10 showed stronger inhibition against α-glucosidase.<b>Conclusion:</b> So, it is concluded that the most potent derivatives can be used as lead compounds in novel drug design of antiviral antidiabetic agents.
Authors
- Breena Awan (ORCID: https://orcid.org/0000-0003-1100-9062)
- Farhat Ullah (ORCID: https://orcid.org/0000-0001-7907-0842)
- Mohsin Abbas Khan (ORCID: https://orcid.org/0000-0002-3178-5467)
- Muhammad Toseef Akram (ORCID: https://orcid.org/0009-0006-2043-2937)
- Irshad Ahmad (ORCID: https://orcid.org/0000-0002-0451-6675)
- Muhammad Rizwan Khan (ORCID: https://orcid.org/0000-0002-8094-7522)
- Zarmeena Yasmeen (ORCID: https://orcid.org/0000-0003-4395-291X)
Institutions
- Islamia University of Bahawalpur (PK)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1080/17568919.2024.2385294
- Citations
- 3
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.75