Proteome- and Transcriptome-Wide Genetic Analysis Identifies Biological Pathways and Candidate Drug Targets for Preeclampsia
This investigation identified multiple targetable proteins linked to cardiovascular, inflammatory, and coagulation pathways, with SERPINE2, PZP, FGF5, FES, and ANP identified as pivotal proteins with likely causal roles in the development of preeclampsia. The identification of these potential targets may guide the development of targeted therapies for preeclampsia.
Authors
- Liam Gaziano (ORCID: https://orcid.org/0000-0003-2059-8081)
- Michael C. Honigberg (ORCID: https://orcid.org/0000-0001-8630-5021)
- Satoshi Yoshiji (ORCID: https://orcid.org/0000-0001-8863-2413)
- Art Schuermans (ORCID: https://orcid.org/0000-0001-8146-9692)
- Pradeep Natarajan (ORCID: https://orcid.org/0000-0001-8402-7435)
- Maddalena Ardissino (ORCID: https://orcid.org/0000-0002-2654-8117)
- Buu Minh Thanh Truong (ORCID: https://orcid.org/0000-0003-0043-0812)
- Antonio de Marvao (ORCID: https://orcid.org/0000-0001-9095-5887)
- Fu Siong Ng (ORCID: https://orcid.org/0000-0002-8681-4368)
- Kypros H. Nicolaides (ORCID: https://orcid.org/0000-0003-1266-0711)
- Eric A. W. Slob (ORCID: https://orcid.org/0000-0002-1644-0735)
- Stephen Burgess (ORCID: https://orcid.org/0000-0001-5365-8760)
- Adam S. Butterworth (ORCID: https://orcid.org/0000-0002-6915-9015)
- Alec Morley (ORCID: https://orcid.org/0009-0005-6021-2093)
Institutions
- Broad Institute (US)
- Harvard University (US)
- VA Boston Healthcare System (US)
- British Heart Foundation (GB)
- National Institute for Health and Care Research (GB)
- Massachusetts General Hospital (US)
- Cambridge School (PT)
- Lung Institute (US)
- Medical Genetics Center (DE)
- MRC Biostatistics Unit (GB)
- Health Data Research UK (GB)
- King's College Hospital (GB)
- Center for Systems Biology (US)
- MRC London Institute of Medical Sciences (GB)
- Health and Human Development (2HD) Research Network (CM)
- Massachusetts Institute of Technology (US)
- Canisius College (US)
- Erasmus University Rotterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Circulation Genomic and Precision Medicine
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1161/circgen.124.004755
- Citations
- 10
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 5.83
Funders
- American Heart Association
- AstraZeneca
- Sanofi
- Biogen
- Regeneron Pharmaceuticals
- National Institute for Health and Care Research
- British Heart Foundation
- Fetal Medicine Foundation
- Genentech
- NIHR Cambridge Biomedical Research Centre
- National Heart, Lung, and Blood Institute