Mendelian Randomization and Bayesian Colocalization Analysis Implicate Glycoprotein VI as a Potential Drug Target for Cardioembolic Stroke in South Asian Populations
Our joint Mendelian randomization and colocalization analyses suggest that genetically predicted GP6 is potentially causally associated with cardioembolic stroke risk in individuals of South Asian ancestry. As genetic data on individuals of South Asian ancestry increase, future Mendelian randomization studies with larger sample size for plasma GP6 levels should be implemented to further validate our findings. Additionally, clinical studies will be necessary to verify GP6 as a therapeutic target for cardioembolic stroke in South Asians.
Authors
- James Yarmolinsky (ORCID: https://orcid.org/0000-0003-4371-0873)
- Alexander Smith (ORCID: https://orcid.org/0000-0001-6418-613X)
- Marie‐Joe Dib (ORCID: https://orcid.org/0000-0001-7591-5684)
- Ioanna Tzoulaki (ORCID: https://orcid.org/0000-0002-4275-9328)
- Dipender Gill (ORCID: https://orcid.org/0000-0001-7312-7078)
- Devendra Meena
- Abbas Dehghan (ORCID: https://orcid.org/0000-0001-6403-016X)
- Ganesh Chauhan (ORCID: https://orcid.org/0000-0002-8564-5021)
- Anand K. Rohatgi (ORCID: https://orcid.org/0000-0003-0164-2382)
- Siwei Wu
Institutions
- Academy of Athens (GR)
- Hospital of the University of Pennsylvania (US)
- Rajendra Institute of Medical Sciences (IN)
- UK Dementia Research Institute (GB)
- Imperial College London (GB)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1161/jaha.124.035008
- Citations
- 13
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 7.15
Funders
- National Institute for Health and Care Research
- British Heart Foundation
- UK Dementia Research Institute
- National Institutes of Health
- Medical Research Council
- NIHR Imperial Biomedical Research Centre