Evidence for ~12-h ultradian gene programs in humans
Mice and many marine organisms exhibit ~12-h ultradian rhythms, however, direct evidence of ~12-h ultradian rhythms in humans is lacking. Here, we performed prospective, temporal transcriptome profiling of peripheral white blood cells from three healthy humans. All three participants independently exhibited robust ~12-h transcriptional rhythms in molecular programs involved in RNA and protein metabolism, with strong homology to circatidal gene programs previously identified in Cnidarian marine species.
Authors
- Rosemary E. Andrews
- Pouneh K. Fazeli (ORCID: https://orcid.org/0000-0003-1731-2927)
- Silvia Liu (ORCID: https://orcid.org/0000-0002-1840-9520)
- William A. Dion (ORCID: https://orcid.org/0000-0002-7697-9433)
- Bokai Zhu (ORCID: https://orcid.org/0000-0003-0827-5757)
- Michelle Sun (ORCID: https://orcid.org/0009-0000-8371-5930)
- Matthew L. Steinhauser (ORCID: https://orcid.org/0000-0001-5287-9246)
- Saad Irfan (ORCID: https://orcid.org/0000-0002-7377-9858)
- Ankit X. Sharma (ORCID: https://orcid.org/0000-0001-5093-6753)
- Natalie L David
- Tânia Amorim (ORCID: https://orcid.org/0000-0002-2193-4190)
- Nandini Doshi (ORCID: https://orcid.org/0000-0002-4146-8932)
- Tristan Pesaresi (ORCID: https://orcid.org/0000-0003-1697-5155)
- Lauren B Siegel
- Hanwen Li (ORCID: https://orcid.org/0000-0002-3974-1506)
- G. V. Naveen Kumar
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- npj Biological Timing and Sleep
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1038/s44323-024-00005-1
- Citations
- 12
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Office of Dietary Supplements
- University of Pittsburgh
- National Institutes of Health
- Center for Research Computing, University of Pittsburgh