Impact of intra‐tumoral immunity on predicting response and survival after neoadjuvant cisplatin‐based chemotherapy in patients with muscle invasive bladder cancer
In the current study, we demonstrated that lower NLR levels and increased CD3<sup>+</sup> T cells and B cell infiltration are associated with improved response and long-term outcomes in patients with MIBC receiving NAC. These findings suggest that the impact of immune environment should be considered in determining the clinical outcome of MIBC patients treated with NAC.
Authors
- Jennifer Linehan (ORCID: https://orcid.org/0000-0001-7519-4098)
- Jane Choe (ORCID: https://orcid.org/0000-0001-8422-7410)
- Warren M. Allen
- Daria M. Kessler
- Steven Kolker
- Xinmin Li (ORCID: https://orcid.org/0000-0002-5544-793X)
- Alberto Mendoza (ORCID: https://orcid.org/0000-0003-4849-1593)
- Maria Libera Ascierto (ORCID: https://orcid.org/0009-0008-8904-1613)
- Przemyslaw Twardowski
- Gianna Jimenez
Institutions
- Providence College (US)
- Saint John's Health Center (US)
- University of Glasgow (GB)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/cam4.70088
- Citations
- 4
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.29