Author profile

Endothelial cell morphology and alignment are directly linked to cytoskeletal structure and organization within the cell while agonist directed signaling pathways are often mediated through these alterations. My research delves into the critical role of the cytoskeleton in regulating endothelial cell function. This makes the journal Cytoskeleton an ideal fit as it focuses on the implication of the cytoskeletal network in cellular processes. Moreover, it allows me to increase the visibility of my work and reach fellow researchers in the field. The lab's research centers on understanding how physical forces influence the behavior of cells and tissues. With a particular focus on the cardiovascular system, we investigate the mechanisms by which the force of blood flow, or shear stress, affects the cells lining blood vessels. To accomplish this, we employ techniques such as atomic force microscopy to meticulously examine the three-dimensional structure of living cells, two photon microscopy to assess plasma membrane composition and dynamics as well as molecular biology protocols to tease out critical cell signaling pathways. Complementing this, computational fluid dynamics is used to model and predict the distribution of forces exerted by blood flow on these cells based on their observed shape. By combining these experimental and computational approaches, we aim to elucidate the complex interplay between mechanical forces and cellular behavior in the cardiovascular system to ultimately inform treatments for cardiovascular diseases. I find the interplay between inflammatory signaling and cytoskeletal remodeling/ barrier function to be really exciting. As this is one of the early events in the formation of atherosclerotic plaques, it presents itself as a prime target for therapeutic intervention. I'm also really interested in understanding how endothelial cells prioritize the external cues they receive. For instance, whether pharmacological activation of the cytoskeleton can circumvent shear stress cues and whether this prioritization is fluid in a variable in vivo environment. I would take my parents on a global tour of natural ecosystems and wonders of the world that are under threat of disappearance. The Alaskan tundra, the great barrier reef, Venice, and the Sundarbans to name a few. Open Spotify on my phone and play my morning tunes playlist—a collection of video game soundtracks. Followed by brushing my teeth and taking the dog out for a long walk.