Landscape of Glycolytic Metabolites and Their Regulating Proteins in Myocardium from Human Heart Failure with Preserved Ejection Fraction
Human HFpEF myocardium exhibits reduced glycolytic and ancillary pathway intermediates and expression of their synthesizing proteins. This combines features reported in HF with reduced ejection fraction and obesity/diabetes that likely exacerbate metabolic inflexibility.
Authors
- Farnaz Farshidfar (ORCID: https://orcid.org/0000-0003-4163-2648)
- Mariam Meddeb (ORCID: https://orcid.org/0000-0002-6922-1587)
- Virginia S. Hahn (ORCID: https://orcid.org/0000-0002-0578-2668)
- Liang Zhao (ORCID: https://orcid.org/0000-0002-2126-6778)
- Seoyoung Kwon
- Mohammad Keykhaei (ORCID: https://orcid.org/0000-0001-5728-7848)
- Kavita Sharma (ORCID: https://orcid.org/0000-0002-4264-1717)
- Erika L. Pearce (ORCID: https://orcid.org/0000-0001-5592-5439)
- David A. Kass (ORCID: https://orcid.org/0000-0003-1596-2299)
- Navid Koleini (ORCID: https://orcid.org/0000-0003-3021-3894)
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Complete Omics (United States) (US)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1002/ejhf.3389
- Citations
- 22
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 8.84
Funders
- American Heart Association
- Amgen
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- University of Pennsylvania
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases
- NHLBI Division of Intramural Research