Bariatric-induced microbiome changes alter MASLD development in association with changes in the innate immune system
Our findings suggest surgery induced microbial changes significantly reduce inflammatory markers and fatty liver progression. The results indicate a potential causal link between the microbiome and the host immune system, possibly mediated through modulation of liver NKT and Kupffer cells.
Authors
- Julianne C. Yang (ORCID: https://orcid.org/0000-0001-5898-7221)
- Erik Dutson (ORCID: https://orcid.org/0000-0001-7126-1468)
- Zhengwen Zhang (ORCID: https://orcid.org/0000-0002-1561-0923)
- Tien S. Dong (ORCID: https://orcid.org/0000-0003-0105-8063)
- William Katzka (ORCID: https://orcid.org/0000-0002-5926-1235)
- Jonathan P. Jacobs (ORCID: https://orcid.org/0000-0003-4698-0254)
- Emeran A. Mayer (ORCID: https://orcid.org/0000-0003-3923-3349)
- Anna Balioukova
- Laura L. Hernandez (ORCID: https://orcid.org/0000-0001-7591-5203)
- Nerea Arias-Jayo (ORCID: https://orcid.org/0000-0002-0726-0177)
- Venu Lagishetty (ORCID: https://orcid.org/0000-0001-6500-8255)
- Candace Chang (ORCID: https://orcid.org/0000-0002-1568-7648)
- Simer Shera
- Madelaine Leitman (ORCID: https://orcid.org/0009-0003-0868-0733)
- Yijun Chen (ORCID: https://orcid.org/0000-0002-4920-152X)
- Joseph R. Pisegna
- Zhaoping Li (ORCID: https://orcid.org/0000-0002-8662-4310)
- Claudia P. Sanmiguel
- Shrey Pawar
Institutions
- University of California, Los Angeles (US)
- UCLA Health (US)
- VA Greater Los Angeles Healthcare System (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-08-09
- DOI
- https://doi.org/10.3389/fmicb.2024.1407555
- Citations
- 8
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Institutes of Health