Cardiovascular responses to experimental weight gain in humans: a feasibility study
Our overfeeding regimen resulted in moderate weight gain and significant increases in BP. An increase in CO is likely to be the dominant mechanism underlying the observed BP changes, with decreases in PVR partially compensating for these effects. Experimental weight gain, coupled with detailed cardiovascular phenotyping, is a feasible model to examine potential mechanisms underlying obesity-associated hypertension in young adults.
Authors
- Ian B. Wilkinson (ORCID: https://orcid.org/0000-0001-6598-9399)
- Kaisa Mäki-Petäjä (ORCID: https://orcid.org/0000-0001-7312-6200)
- Annette Hubsch
- Domonkos Cseh (ORCID: https://orcid.org/0000-0003-1955-5148)
- Carmel M. McEniery (ORCID: https://orcid.org/0000-0003-3636-0705)
- Jessica Middlemiss
Institutions
- Apple (Israel) (IL)
- University of Cambridge (GB)
- Addenbrooke's Hospital (GB)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2024-08-08
- DOI
- https://doi.org/10.1097/hjh.0000000000003830
- Citations
- 1
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- NIHR Cambridge Biomedical Research Centre