Dysregulated lipid metabolism and intervertebral disc degeneration: the important role of ox-LDL/LOX-1 in endplate chondrocyte senescence and calcification
So our study revealed that ox-LDL/LOX-1-induced EPCs senescence and calcification through ROS/P38-MAPK/NF-κB signaling pathway, providing information on understanding the link between lipid metabolism disorders and IDD.
Authors
- Zhenming Hu (ORCID: https://orcid.org/0000-0001-5786-5919)
- Tan Bing
- Jie Hao (ORCID: https://orcid.org/0000-0001-5781-2534)
- Nian Zhou (ORCID: https://orcid.org/0000-0002-2252-7108)
- Zhiwei Zhang (ORCID: https://orcid.org/0000-0002-0556-8645)
- Bin Yu (ORCID: https://orcid.org/0000-0002-3109-2062)
- MA Zhao-xin
- Jisheng Wang (ORCID: https://orcid.org/0000-0003-2949-3825)
- Xiang Shanlin
- Cao Ruichao
Institutions
- Mianyang Third People's Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1186/s10020-024-00887-8
- Citations
- 17
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 7.22
Funders
- National Natural Science Foundation of China