Melatonin Alleviates Liver Mitochondrial Dysfunction in Leptin-Deficient Mice
Despite efforts to elucidate the cellular adaptations induced by obesity, cellular bioenergetics is currently considered a crucial target. New strategies to delay the onset of the hazardous adaptations induced by obesity are needed. Therefore, we evaluated the effects of 4 weeks of melatonin treatment on mitochondrial function and lipid metabolism in the livers of leptin-deficient mice. Our results revealed that the absence of leptin increased lipid storage in the liver and induced significant mitochondrial alterations, which were ultimately responsible for defective ATP production and reactive oxygen species overproduction. Moreover, leptin deficiency promoted mitochondrial biogenesis, fusion, and outer membrane permeabilization. Melatonin treatment reduced the bioenergetic deficit found in ob/ob mice, alleviating some mitochondrial alterations in the electron transport chain machinery, biogenesis, dynamics, respiration, ATP production, and mitochondrial outer membrane permeabilization. Given the role of melatonin in maintaining mitochondrial homeostasis, it could be used as a therapeutic agent against adipogenic steatosis.
Authors
- Ana Coto‐Montes (ORCID: https://orcid.org/0000-0002-6609-6258)
- Gonçalo C. Pereira (ORCID: https://orcid.org/0000-0001-9638-0615)
- Adrian Rubio‐González (ORCID: https://orcid.org/0000-0002-1458-2115)
- Beatriz de Luxán‐Delgado (ORCID: https://orcid.org/0000-0003-4507-716X)
- Ignacio Vega‐Naredo (ORCID: https://orcid.org/0000-0003-1993-6725)
- José Antonio Boga (ORCID: https://orcid.org/0000-0002-5500-9972)
- Yaiza Potes (ORCID: https://orcid.org/0000-0002-4687-6230)
- Nerea Menéndez-Coto (ORCID: https://orcid.org/0009-0007-4796-4965)
- Juan Carlos Bermejo-Millo (ORCID: https://orcid.org/0000-0001-8552-8039)
- Beatriz Caballero (ORCID: https://orcid.org/0000-0003-0242-9620)
- Cristina Cachán-Vega (ORCID: https://orcid.org/0000-0001-7244-7862)
- Claudia García-González (ORCID: https://orcid.org/0000-0002-8422-230X)
- Eduardo Antuña (ORCID: https://orcid.org/0000-0003-1016-6306)
- Juan J. Pérez-Solano (ORCID: https://orcid.org/0000-0002-8584-248X)
Institutions
- Universidad de Oviedo (ES)
- University of Bristol (GB)
- Hospital Universitario Central de Asturias (ES)
- Hospital Monte Naranco (ES)
- Instituto de Investigación Sanitaria del Principado de Asturias (ES)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2024-08-08
- DOI
- https://doi.org/10.3390/ijms25168677
- Citations
- 3
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.98
Funders
- Fundación Mutua Madrileña
- Universidad de Oviedo