An Implantable Self-Driven Diaphragm Pacing System Based on a Microvibration Triboelectric Nanogenerator for Phrenic Nerve Stimulation

Spinal cord injury poses considerable challenges, particularly in diaphragm paralysis. To address limitations in existing diaphragm pacing technologies, we report an implantable, self-driven diaphragm pacing system based on a microvibration triboelectric nanogenerator (MV-TENG). Leveraging the efficient MV-TENG, the system harvests micromechanical energy and converts this energy into pulses for phrenic nerve stimulation. In vitro tests confirm a stable MV-TENG output, while subcutaneous implantation of the device in rats results in a constant amplitude over 4 weeks with remarkable energy-harvesting efficacy. The system effectively induces diaphragmatic motor-evoked potentials, triggering contractions of the diaphragm. This proof-of-concept system has potential clinical applications in implantable phrenic nerve stimulation, presenting a novel strategy for advancing next-generation diaphragm pacing devices.

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Publication Details

Journal
ACS Applied Materials & Interfaces
Published
2024-08-09
DOI
https://doi.org/10.1021/acsami.4c03715
Citations
11
Primary Topic
Neuroscience of respiration and sleep
Type
article
Field-Weighted Citation Impact
3.01

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article

An Implantable Self-Driven Diaphragm Pacing System Based on a Microvibration Triboelectric Nanogenerator for Phrenic Nerve Stimulation

Guangzhi Ning, Hao Zhong, Cong Xing, Shiqing Feng et al.
11 citations
ACS Applied Materials & Interfaces
Neuroscience of respiration and sleep
3.01
article

An Implantable Self-Driven Diaphragm Pacing System Based on a Microvibration Triboelectric Nanogenerator for Phrenic Nerve Stimulation

Guangzhi Ning, Hao Zhong, Cong Xing, Shiqing Feng, Zhigang Qu, Mi Zhou, Song Liu, Qi Zhang, Yang An, Junrui Guo, Ke Zhang
article en
11 citations

Abstract

Spinal cord injury poses considerable challenges, particularly in diaphragm paralysis. To address limitations in existing diaphragm pacing technologies, we report an implantable, self-driven diaphragm pacing system based on a microvibration triboelectric nanogenerator (MV-TENG). Leveraging the efficient MV-TENG, the system harvests micromechanical energy and converts this energy into pulses for phrenic nerve stimulation. In vitro tests confirm a stable MV-TENG output, while subcutaneous implantation of the device in rats results in a constant amplitude over 4 weeks with remarkable energy-harvesting efficacy. The system effectively induces diaphragmatic motor-evoked potentials, triggering contractions of the diaphragm. This proof-of-concept system has potential clinical applications in implantable phrenic nerve stimulation, presenting a novel strategy for advancing next-generation diaphragm pacing devices.

ACS Applied Materials & InterfacesVol. 16(33)
Tianjin University of Science and Technology (CN), Tianjin Medical University General Hospital (CN), China International Science and Technology Cooperation (CN), Spinal Cord Injury Ontario (CA), Structural Integrity Associates (United States) (US)
National Natural Science Foundation of China, Tianjin Medical University
Openalex Percentile: Top 9%
Neuroscience of respiration and sleep
3.01
DOIOpen Access PDFOpenAlex
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