The Anti-Constipation Effect of Bifidobacterium Longum W11 Is Likely Due to a Key Genetic Factor Governing Arabinan Utilization
Recent investigations have highlighted, both experimentally and clinically, that probiotic strains equipped with arabinofuranosidase, in particular <i>abfA</i> and <i>abfB</i>, favor regular intestinal motility, thus counteracting constipation. By analyzing the gene expression and the proliferative response in the presence of arabinan of the probiotic <i>B. longum</i> W11, a strain previously validated as an anti-constipation probiotic, we have speculated that its response mechanism to arabinan can effectively explain its clinical action. Our approach could be used in the future to select probiotics endowed with arabinofuranosidase-related anti-constipation effects.
Authors
- Sara Soldi (ORCID: https://orcid.org/0000-0001-5670-1306)
- Ilaria Cavecchia (ORCID: https://orcid.org/0009-0007-2326-2328)
- Chiara Maria Palazzi (ORCID: https://orcid.org/0009-0006-8807-3029)
- Valeria Sagheddu
- Francesco Di Pierro (ORCID: https://orcid.org/0000-0001-6654-8675)
- Nicola Zerbinati (ORCID: https://orcid.org/0000-0003-2177-9677)
- Mariarosaria Matera
- Alexander Bertuccioli (ORCID: https://orcid.org/0000-0002-3922-9115)
- Massimiliano Cazzaniga
- Edoardo Labrini
Institutions
- University of Insubria (IT)
- University of Urbino (IT)
- Velleja Research (IT)
- Ospedale Koelliker (IT)
- Ospedale Misericordia - Grosseto (IT)
Publication Details
- Journal
- Microorganisms
- Published
- 2024-08-09
- DOI
- https://doi.org/10.3390/microorganisms12081626
- Citations
- 4
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 1.39