Perplexity of utterances in untreated first-episode psychosis: an ultra–high field MRI dynamic causal modelling study of the semantic network
As an explanation for peculiar speech in psychosis, these results index a shift in the excitatory-inhibitory balance regulating information flow across the semantic network, confined to 2 regions that were previously linked specifically to the executive control of meaning. Based on our approach of combining a large language model with causal connectivity estimates, we propose loss in semantic control as a potential neurocognitive mechanism contributing to disorganization in psychosis.
Authors
- María Francisca Alonso-Sánchez (ORCID: https://orcid.org/0000-0002-6638-1374)
- Wolfram Hinzen (ORCID: https://orcid.org/0000-0002-6159-4215)
- Joseph S. Gati (ORCID: https://orcid.org/0000-0003-3205-7274)
- Lena K. Palaniyappan (ORCID: https://orcid.org/0000-0003-1640-7182)
- Rui He (ORCID: https://orcid.org/0000-0001-6999-1920)
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Western University (CA)
- Universitat Pompeu Fabra (ES)
- Douglas Mental Health University Institute (CA)
- University of Valparaíso (CL)
Publication Details
- Journal
- Journal of Psychiatry and Neuroscience
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1503/jpn.240031
- Citations
- 14
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.46