Application of Solution Blow Spinning (SBS) Through Airbrush Pen for in situ Generation of Barrier Membranes

Objective This study has evaluated the applicability and microstructure of polymeric membranes produced by poly(vinyl alcohol) (PVA) and poly(lactic acid) (PLA) solutions developed through an airbrush pen by the Solution Blow Spinning (SBS) technique.Materials and Methods Polymeric solutions with different concentrations were used: PLA 20%, PLA 25% and PLA 40% in CH3Cl, PLA 20% in 2,2,2-trifluoroethanol (PLA 20%/TFE), PVA 20%, PVA 25% and PVA 40% and 20% PVA with 10% microcrystalline cellulose (PVA 20%/MC 10%) in water. A commercial airbrush device were used to deposit the polymer membranes, with distances of 5 and 10 cm from the vitreous, aluminum and bone surfaces. Polymer coverage of areas of interest and bone defects were evaluated by optical microscopy, scanning electron microscopy (SEM) and 3D scanning.Results Only a distance of 10 cm between the tip and the collector produced homogeneous membranes under the experimental conditions. PLA solutions at PLA 20%, PLA 25% and PLA 20%/TFE formed polymeric membranes, while depositions of PVA 20%, PVA 25% and PVA 20%/MC 10% created adherent films on structures with the absence of fibrous structures on surfaces. PLA deposition ensured complete closure of bone defects.Conclusions The use of polymeric solutions, using the SBS technique, depositing membranes using an airbrush pen demonstrated the formation of membranes at concentrations of PLA 20%, PLA 25% and PLA 20%/TFE.Practical Implications The direct deposition of polymeric membranes at the surgical site may represent an advance in guided bone regeneration, allowing the dental surgeon autonomy in the deposition of barrier membranes.