The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response
ERAP2 is upregulated in the inflamed IBD colon mucosa, and expression proficiency is highly correlated with genotype of rs2910686. While the SNP rs2248374 is commonly used to determine ERAP2 expressional proficiency, our data confirms that mechanisms independent of this SNP can lead to ERAP2 deficiency. Our data demonstrates that epithelial ERAP2 presence affects the inflammatory response in colonoids, suggesting a pleiotropic role of ERAP2 beyond MHC class I antigen processing.
Authors
- Marianne Doré Hansen (ORCID: https://orcid.org/0000-0003-0488-3368)
- Atle van Beelen Granlund (ORCID: https://orcid.org/0000-0001-8117-2637)
- Siri Sæterstad
- Ann Elisabet Østvik (ORCID: https://orcid.org/0000-0001-6895-1070)
- Torunn Bruland (ORCID: https://orcid.org/0000-0002-1568-2476)
Institutions
- Norwegian University of Science and Technology (NO)
- St Olav's University Hospital (NO)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1186/s12967-024-05532-w
- Citations
- 5
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- Norges Teknisk-Naturvitenskapelige Universitet
- Helse Midt-Norge
- St. Olavs Hospital Universitetssykehuset i Trondheim
- Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet
- Faculty of Medicine and Health, University of Sydney
- Norwegian Institute of Public Health