Serial Cerebrospinal Fluid Sampling Reveals Trajectories of Potential Synaptic Biomarkers in Early Stages of Alzheimer’s Disease
CSF synaptic proteins showed different slopes over time, suggesting complex synaptic dynamics. High levels of especially SNAP-25 may have value for prediction of cognitive decline in early AD stages, while increase in NfL over time correlates better with cognitive decline in later stages.
Authors
- Ann Brinkmalm (ORCID: https://orcid.org/0000-0002-7396-3233)
- Flora H. Duits
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Wiesje M. van der Flier (ORCID: https://orcid.org/0000-0001-8766-6224)
- Johanna Nilsson (ORCID: https://orcid.org/0000-0002-2856-6060)
- Charlotte Elisabeth Teunissen (ORCID: https://orcid.org/0000-0002-4061-0837)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
Institutions
- University of Wisconsin–Madison (US)
- Sahlgrenska University Hospital (SE)
- Amsterdam Neuroscience (NL)
- UK Dementia Research Institute (GB)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-08-09
- DOI
- https://doi.org/10.3233/jad-240610
- Citations
- 7
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Biogen
- Familjen Erling-Perssons Stiftelse
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- Roche Nederland
- Amsterdam University Medical Centers
- National Institute for Health and Care Research
- University College London
- European Commission
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Eisai
- Hjärnfonden
- Vetenskapsrådet
- Stichting Dioraphte
- Alzheimer Nederland
- UK Dementia Research Institute
- Amsterdam Neuroscience
- GIESKES-STRIJBIS FONDS
- HORIZON EUROPE Framework Programme