Implementation and Assessment of Tau Thresholds in Non-Demented Individuals as Predictors of Cognitive Decline in Tau Imaging Studies
When using 18F-flortaucipir, meta temporal suprathreshold classification was associated with increased risk of cognitive decline, suggesting that abnormal tau deposition in the cortex predicts decline. Likewise, the application of multiple levels of tau clearly predicts the distinctive cognitive trajectories in the new NIA-AA biological staging framework.
Authors
- Vincent Doré (ORCID: https://orcid.org/0000-0002-8051-0558)
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- C. Elizabeth Shaaban (ORCID: https://orcid.org/0000-0002-3016-1951)
- Miloš D. Ikonomović (ORCID: https://orcid.org/0000-0002-8745-3293)
- Ann D. Cohen (ORCID: https://orcid.org/0000-0001-7395-9624)
- Chester A. Mathis (ORCID: https://orcid.org/0000-0001-9811-0950)
- Pierrick Bourgeat (ORCID: https://orcid.org/0000-0002-2605-4766)
- Antoine Leuzy (ORCID: https://orcid.org/0000-0003-4542-7879)
- Beth E. Snitz (ORCID: https://orcid.org/0000-0002-9978-1374)
- Howard Jay Aizenstein (ORCID: https://orcid.org/0000-0003-4897-6582)
- Victor L. Villemagne (ORCID: https://orcid.org/0000-0002-5832-9875)
- Alexandra Gogola (ORCID: https://orcid.org/0000-0002-8798-1715)
- Brian J. Lopresti
- Davneet Minhas (ORCID: https://orcid.org/0000-0002-0217-6777)
- Cristy Matan
- N. Scott Mason (ORCID: https://orcid.org/0000-0001-7739-3285)
- Oscar L. López (ORCID: https://orcid.org/0000-0002-8546-8256)
Institutions
- Commonwealth Scientific and Industrial Research Organisation (AU)
- University of Pittsburgh (US)
- Critical Path Institute (US)
- Geriatric Research Education and Clinical Center (US)
- CSIRO Health and Biosecurity (AU)
- Austin Health (AU)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-08-09
- DOI
- https://doi.org/10.3233/jad-240543
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research