Immune and inflammation features of severe and critical Omicron infected patients during Omicron wave in China
This present study assessed the dynamic changes of SARS-CoV-2-specific antibodies, immune cells and inflammatory indexes between severely and critically ill PIWO. Critical and dead PIWO featured compromised humoral immune response and excessive inflammation, which broadened the understanding of the pathophysiology of Omicron infection and provides warning markers for severe disease and poor prognosis.
Authors
- Jingjing Cui (ORCID: https://orcid.org/0000-0003-1540-1467)
- Yongzhe Li (ORCID: https://orcid.org/0000-0002-8267-0985)
- Shuqin Guo
- Sha Feng
- Xin Liu (ORCID: https://orcid.org/0000-0002-2344-3766)
- Haoting Zhan (ORCID: https://orcid.org/0000-0001-5934-9141)
- Guo Yaping (ORCID: https://orcid.org/0000-0002-2614-3048)
- Linlin Cheng (ORCID: https://orcid.org/0000-0003-1924-3363)
- Xiaomeng Li (ORCID: https://orcid.org/0000-0003-3966-2864)
- Xiaoyan Li (ORCID: https://orcid.org/0000-0002-7454-7821)
- Yongmei Liu (ORCID: https://orcid.org/0000-0002-6562-1858)
- Haolong Li (ORCID: https://orcid.org/0000-0002-7865-3306)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Peking University People's Hospital (CN)
- Baoding People's Hospital (CN)
- Baoding No.1 Central Hospital
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1186/s12879-024-09652-y
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- China Postdoctoral Science Foundation
- Peking Union Medical College Hospital
- National Key Research and Development Program of China