Long Non-Coding RNA Profile in Genetic Symptomatic and Presymptomatic Frontotemporal Dementia: A GENFI Study
NEAT1 and NORAD are upregulated in C9ORF72 SMC and GAS5 levels are downregulated in GRN SMC, underlining lncRNAs' relevance in FTD and their potential for biomarker development. Further validation and mechanistic studies are crucial for clinical implications.
Authors
- John Cornelis Van Swieten (ORCID: https://orcid.org/0000-0001-6278-6844)
- Manuela Pintus (ORCID: https://orcid.org/0000-0003-1994-2682)
- Sandro Sorbi (ORCID: https://orcid.org/0000-0002-0380-6670)
- Caroline Graff (ORCID: https://orcid.org/0000-0002-9949-2951)
- Andrea Arighi (ORCID: https://orcid.org/0000-0003-2865-3970)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- James B. Rowe (ORCID: https://orcid.org/0000-0001-7216-8679)
- Alexander Gerhard (ORCID: https://orcid.org/0000-0002-8071-6062)
- Christopher Butler (ORCID: https://orcid.org/0000-0002-7502-9284)
- María Serpente (ORCID: https://orcid.org/0000-0003-0725-1403)
- Matthis Synofzik (ORCID: https://orcid.org/0000-0002-2280-7273)
- Johannes Levin (ORCID: https://orcid.org/0000-0001-5092-4306)
- Alexandre de Mendonça (ORCID: https://orcid.org/0000-0002-0488-1453)
- Eve Ferry‐Bolder
- Isabelle Le Ber (ORCID: https://orcid.org/0000-0002-2508-5181)
- Marina Arcaro (ORCID: https://orcid.org/0000-0002-3821-0682)
- Raquel Sánchez‐Valle (ORCID: https://orcid.org/0000-0001-7750-896X)
- Harro Seelaar (ORCID: https://orcid.org/0000-0003-1989-7527)
- Pietro Tiraboschi (ORCID: https://orcid.org/0000-0002-2171-1720)
- Phoebe H. Foster (ORCID: https://orcid.org/0000-0001-6300-6598)
- Florence Pasquier (ORCID: https://orcid.org/0000-0001-9880-9788)
- Arabella Bouzigues (ORCID: https://orcid.org/0000-0002-0267-8590)
- Lize C. Jiskoot (ORCID: https://orcid.org/0000-0002-1120-1858)
- Vittoria Borracci (ORCID: https://orcid.org/0009-0006-7406-376X)
- Lucy L. Russell
- Jonathan D. Rohrer (ORCID: https://orcid.org/0000-0002-6155-8417)
- Markus Otto (ORCID: https://orcid.org/0000-0003-4273-4267)
- Elizabeth Finger (ORCID: https://orcid.org/0000-0003-4461-7427)
- Luca Sacchi (ORCID: https://orcid.org/0000-0002-3929-9009)
- Chiara Fenoglio (ORCID: https://orcid.org/0000-0001-6332-4721)
- Daniela Galimberti (ORCID: https://orcid.org/0000-0002-9284-5953)
- Emanuela Rotondo (ORCID: https://orcid.org/0000-0001-6134-9407)
- Fermín Moreno (ORCID: https://orcid.org/0000-0001-5200-3164)
- Tiziana Carandini (ORCID: https://orcid.org/0000-0002-0568-7580)
- Barbara Borroni (ORCID: https://orcid.org/0000-0001-9340-9814)
- Rik Vandenberghe
- Laura Ghezzi
- Mario Masellis
- Robert Laforce
- Simon Ducharme (ORCID: https://orcid.org/0000-0002-7309-1113)
- Isabel Santana
Institutions
- Western University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Centre National de la Recherche Scientifique (FR)
- Sunnybrook Health Science Centre (CA)
- Karolinska University Hospital (SE)
- University of Lisbon (PT)
- Inserm (FR)
- University of Toronto (CA)
- University of Milan (IT)
- Universität Ulm (DE)
- Université de Lille (FR)
- University of Cambridge (GB)
- Douglas Mental Health University Institute (CA)
- Instituto de Salud Carlos III (ES)
- German Center for Neurodegenerative Diseases (DE)
- Health Sciences Centre (CA)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Karolinska Institutet (SE)
- University of Manchester (GB)
- Sorbonne Université (FR)
- University of Oxford (GB)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Assistance Publique – Hôpitaux de Paris (FR)
- Biogipuzkoa Health Research Institute (ES)
- Occupational Cancer Research Centre (CA)
- Munich Cluster for Systems Neurology (DE)
- Hospital Clínic de Barcelona (ES)
- Don Carlo Gnocchi Foundation (IT)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Klinikum Arnsberg (DE)
- Hertie Institute for Clinical Brain Research (DE)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Université Laval (CA)
- University of Florence (IT)
- University College London (GB)
- Imperial College London (GB)
- McGill University (CA)
- Universitat de Barcelona (ES)
- University of Coimbra (PT)
- University of Brescia (IT)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Erasmus University Rotterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-08-09
- DOI
- https://doi.org/10.3233/jad-240557
- Citations
- 4
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- Wellcome Trust
- Weston Brain Institute
- National Institute for Health and Care Research
- University of Cambridge
- University College London
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Ministero della Salute
- Stichting Dioraphte
- Alzheimer Nederland
- Canadian Institutes of Health Research
- Medical Research Council
- Instituto de Salud Carlos III
- NIHR Cambridge Biomedical Research Centre