Pharmacokinetics of a potential antiepileptic drug GIZh-298
GIZh-298 pharmacokinetics was studied in rats after different dosage regimens. The aim of this study was to study GIZh-298 pharmacokinetics after its multiple intragastric administration. Methods. The study was conducted on outbred male rats. The concentrations of GIZh-298 in the blood plasma were determined by HPLC with mass-spectrometric detection. Pharmacokinetic parameters were evaluated using a model-independent method. Results. After single and multiple (4 times with a dosage interval of 3 hours) intragastric administrations at 60 mg/kg dose, the test substance in the blood plasma was determined for 4 hours. The mode of administration of GIZh-298 did not affect the value of its half-life and the mean residence time. It has been established that GIZh-298 accumulates in the rats.
Authors
- В. П. Жердев (ORCID: https://orcid.org/0000-0003-2710-7134)
- Оксана Геннадьевна Грибакина (ORCID: https://orcid.org/0000-0002-4604-4346)
- Г. Б. Колыванов (ORCID: https://orcid.org/0000-0002-2571-0047)
- O. Yu. Kravtsova (ORCID: https://orcid.org/0000-0002-0693-2007)
- А. А. Литвин (ORCID: https://orcid.org/0000-0002-2818-3457)
Institutions
- Medical Technologies (Czechia) (CZ)
Publication Details
- Journal
- Pharmacokinetics and Pharmacodynamics
- Published
- 2024-08-08
- DOI
- https://doi.org/10.37489/2587-7836-2024-2-57-61
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00