The aperiodic exponent of neural activity varies with vigilance state in mice and men
Recently the 1/f signal of human electroencephalography has attracted attention, as it could potentially reveal a quantitative measure of neural excitation and inhibition in the brain, that may be relevant in a clinical setting. The purpose of this short article is to show that the 1/f signal depends on the vigilance state of the brain in both humans and mice. Therefore, proper labelling of the EEG signal is important as improper labelling may obscure disease-related changes in the 1/f signal. We demonstrate this by comparing EEG results from a longitudinal study in a genetic mouse model for synaptic dysfunction in schizophrenia and autism spectrum disorders to results from a large European cohort study with schizophrenia and mild Alzheimer's disease patients. The comparison shows when the 1/f is corrected for vigilance state there is a difference between groups, and this effect disappears when vigilance state is not corrected for. In conclusion, more attention should be paid to the vigilance state during analysis of EEG signals regardless of the species.
Authors
- Celso Arango (ORCID: https://orcid.org/0000-0003-3382-4754)
- Freja Gam Østergaard (ORCID: https://orcid.org/0000-0001-7113-1743)
- Nic J.A. van der Wee (ORCID: https://orcid.org/0000-0003-3235-1633)
- Hugh Marston (ORCID: https://orcid.org/0000-0002-7460-0581)
- Brenda W.J.H. Penninx (ORCID: https://orcid.org/0000-0001-7779-9672)
- Martien J. Kas (ORCID: https://orcid.org/0000-0002-4471-8618)
- Gerard R. Dawson (ORCID: https://orcid.org/0000-0002-8624-7500)
- José Luís Ayuso‐Mateos (ORCID: https://orcid.org/0000-0002-7544-826X)
- Inge Winter-van Rossum
- Neetha Das
Institutions
- Universidad Complutense de Madrid (ES)
- Boehringer Ingelheim (Germany) (DE)
- University of Groningen (NL)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- Instituto de Salud Carlos III (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- University Medical Center Utrecht (NL)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Eli Lilly (United Kingdom) (GB)
- Amsterdam Neuroscience (NL)
- Hospital Universitario de La Princesa (ES)
- Structure Fédérative de Recherche en Biologie et Santé de Rennes (FR)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1371/journal.pone.0301406
- Citations
- 6
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- H2020 European Research Council