Molecular and Clinicopathologic Impact of GNAS Variants Across Solid Tumors
Across the assessed cancers, <i>GNAS-</i>mut tumors exhibit a conserved molecular and clinical phenotype defined by mucinous tumor status, increased peritoneal metastasis, poor response to first-line systemic therapy, and worse survival.
Authors
- Oliver Artz (ORCID: https://orcid.org/0000-0002-5708-1281)
- Henry S. Walch (ORCID: https://orcid.org/0000-0003-1188-350X)
- Paul M. Johannet (ORCID: https://orcid.org/0000-0002-9264-8327)
- Benoı̂t Rousseau (ORCID: https://orcid.org/0000-0002-1594-4827)
- Callahan M. Wilde (ORCID: https://orcid.org/0000-0002-3700-1387)
- Andrea Cercek (ORCID: https://orcid.org/0000-0002-5054-8192)
- Nikolaus Schultz (ORCID: https://orcid.org/0000-0002-0131-4904)
- Rona Yaeger (ORCID: https://orcid.org/0000-0002-7233-5454)
- Michael B. Foote (ORCID: https://orcid.org/0000-0003-3027-2405)
- Shrey Patel (ORCID: https://orcid.org/0000-0001-5008-7616)
- Luis Alberto Diaz (ORCID: https://orcid.org/0000-0002-7079-8914)
- Guillem Argilés (ORCID: https://orcid.org/0000-0002-1487-7108)
- Andrea Arfè (ORCID: https://orcid.org/0000-0003-1534-0609)
- Mitesh Patel (ORCID: https://orcid.org/0000-0001-6724-9183)
- Karuna Ganesh (ORCID: https://orcid.org/0000-0001-8095-1372)
- Somer Abdelfattah
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Molecular Oncology (United States) (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1200/jco.24.00186
- Citations
- 12
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 3.42
Funders
- American Association for Cancer Research
- Colorectal Cancer Alliance
- Swim Across America
- National Institutes of Health
- Stand Up To Cancer
- National Cancer Institute