Nocturnal Salivary Cortisol Is an Accurate Non-Invasive Test to Assess Endogenous Hypercortisolism in Children with Obesity and a Clinical Phenotype Suspicious for Cushing’s Syndrome
Salivary cortisol at 11 p.m. is an accurate, feasible, and non-invasive first-line test to assess endogenous hypercortisolism in children with obesity and clinical suspicion of CS. The nSC was also useful in showing that the circadian rhythm of cortisol was preserved in children with exogenous obesity. In patients with nSC ≥8.0 nmol/L, other biochemical assessments and imaging studies are needed to further confirm the aetiology.
Authors
- Andrea Arcari (ORCID: https://orcid.org/0000-0001-7618-1950)
- María Gabriela Ropelato (ORCID: https://orcid.org/0000-0003-0040-1210)
- Ana Vieites
- Analía V. Freire (ORCID: https://orcid.org/0000-0002-3330-5594)
- Débora Braslavsky (ORCID: https://orcid.org/0000-0002-4501-7610)
- Marı́a Gabriela Ballerini (ORCID: https://orcid.org/0000-0003-0312-7421)
- Graciela Testa
- Luciana Brenzoni
- Laura M. De Castro (ORCID: https://orcid.org/0000-0002-2380-8198)
- Ana Keselman (ORCID: https://orcid.org/0000-0002-5612-0445)
- Ignacio Bergadá (ORCID: https://orcid.org/0000-0001-6546-1949)
- María Eugenia Rodríguez (ORCID: https://orcid.org/0000-0003-0604-7208)
- Luciana Daga
- Ana Carolina Arias Cau
- Melina Gil
Institutions
- National University of Jujuy (AR)
- Servicio Diabetología Hospital Córdoba (AR)
- Hospital de Niños de la Santísima Trinidad (AR)
- Hospital General de Niños Ricardo Gutierrez (AR)
Publication Details
- Journal
- Hormone Research in Paediatrics
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1159/000540785
- Citations
- 3
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.07