NDRG1 enhances the sensitivity to Cetuximab by promoting Stat1 ubiquitylation in colorectal cancer
Our study revealed that NDRG1 enhanced the sensitivity to Cetuximab by inhibiting Stat1 expression and promoting its ubiquitination in colorectal cancer, elucidating NDRG1 might be a potential therapeutic target for refractory CTX-resistant CRC tumors. But its clinical value still needs to be validated in a larger sample size as well as a different genetic background.
Authors
- Yanfei Shao (ORCID: https://orcid.org/0000-0003-4228-4833)
- C Zhang
- Ling Huang (ORCID: https://orcid.org/0000-0001-5584-0419)
- Jing Ping Sun (ORCID: https://orcid.org/0000-0003-2110-5189)
- Enkui Zhang
- Minhua Zheng (ORCID: https://orcid.org/0000-0002-9536-8793)
- Yu Wang (ORCID: https://orcid.org/0000-0002-7309-7304)
- Jiang Jiang (ORCID: https://orcid.org/0000-0001-9092-8301)
- Guang Yang (ORCID: https://orcid.org/0000-0001-6079-5093)
- Junjun Ma (ORCID: https://orcid.org/0000-0002-4857-7031)
- Xiao Yang (ORCID: https://orcid.org/0000-0002-0298-9831)
- Lu Zang (ORCID: https://orcid.org/0000-0002-7232-5504)
- Xueliang Zhou (ORCID: https://orcid.org/0000-0001-6973-3112)
- Xiaodong Fan
- Chengsheng Ding
- Shiyuan He (ORCID: https://orcid.org/0009-0005-6287-6969)
Institutions
- University of Alberta (CA)
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1016/j.jare.2024.07.035
- Citations
- 6
- Primary Topic
- Mechanisms of cancer metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University