Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO)
Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project's distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the article includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that patients with cancer could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve relative dose intensity for a curative outcome.
Authors
- Lee Jones (ORCID: https://orcid.org/0000-0002-8030-1211)
- Julia Foldi (ORCID: https://orcid.org/0000-0002-7504-867X)
- Vernon M. Chinchilli (ORCID: https://orcid.org/0000-0001-6488-7809)
- Talya Salz (ORCID: https://orcid.org/0000-0002-4515-6004)
- Guillaume Spielmann (ORCID: https://orcid.org/0000-0001-7024-0972)
- Frank J. Penedo (ORCID: https://orcid.org/0000-0002-2422-2391)
- Cynthia Owusu (ORCID: https://orcid.org/0000-0003-2045-4336)
- Wendy Demark‐Wahnefried (ORCID: https://orcid.org/0000-0001-5241-932X)
- Elena Ratner (ORCID: https://orcid.org/0000-0002-6277-6002)
- Sarah Freylersythe (ORCID: https://orcid.org/0000-0002-9996-5413)
- Ross L. Levine (ORCID: https://orcid.org/0000-0002-7884-1905)
- Helena Furberg (ORCID: https://orcid.org/0000-0003-1887-514X)
- Jeffrey A. Meyerhardt (ORCID: https://orcid.org/0000-0002-1120-0898)
- Andrea Cercek (ORCID: https://orcid.org/0000-0002-5054-8192)
- Jennifer A. Ligibel (ORCID: https://orcid.org/0000-0002-0633-3151)
- Nathan A. Berger (ORCID: https://orcid.org/0000-0001-7086-9885)
- Loretta DiPietro (ORCID: https://orcid.org/0000-0002-3064-3977)
- Christina M. Dieli‐Conwright (ORCID: https://orcid.org/0000-0001-9093-7259)
- Karen Basen‐Engquist (ORCID: https://orcid.org/0000-0001-7299-0646)
- Borsika Adrienn Rabin (ORCID: https://orcid.org/0000-0001-9837-7866)
- Frank M. Perna (ORCID: https://orcid.org/0000-0002-7973-9945)
- Anthony F. Yu (ORCID: https://orcid.org/0000-0002-7120-8285)
- Cynthia A. Thomson (ORCID: https://orcid.org/0000-0003-3645-7048)
- Justin C. Brown (ORCID: https://orcid.org/0000-0001-7540-4913)
- Ashley H. Tjaden (ORCID: https://orcid.org/0000-0002-7674-5071)
- Shengping Yang (ORCID: https://orcid.org/0000-0001-6298-6301)
- Leah M. Ferrucci (ORCID: https://orcid.org/0000-0001-9488-7586)
- Tanya Agurs‐Collins (ORCID: https://orcid.org/0000-0002-4802-9289)
- Kathryn H. Schmitz (ORCID: https://orcid.org/0000-0003-2400-2935)
- Melinda L. Irwin (ORCID: https://orcid.org/0000-0001-7571-0304)
- Kim Robien (ORCID: https://orcid.org/0000-0002-2120-2280)
- Margaret Rosenzweig (ORCID: https://orcid.org/0000-0003-2276-9673)
- Shawna E. Doerksen (ORCID: https://orcid.org/0009-0007-6797-0887)
- William J. Evans (ORCID: https://orcid.org/0000-0001-6757-1471)
- Chaya S. Moskowitz (ORCID: https://orcid.org/0000-0002-2850-8450)
- Sharon L. Edelstein (ORCID: https://orcid.org/0000-0001-8457-4404)
- Bette J. Caan (ORCID: https://orcid.org/0000-0002-5803-310X)
- Brenda Cartmel (ORCID: https://orcid.org/0000-0002-4748-5143)
- Matthew Schlumbrecht (ORCID: https://orcid.org/0000-0002-0257-7327)
- Sheng F. Cai (ORCID: https://orcid.org/0000-0002-2708-887X)
- Jessica M. Scott (ORCID: https://orcid.org/0000-0002-4845-5800)
- Tracy E. Crane (ORCID: https://orcid.org/0000-0002-4288-134X)
- Jennifer W. Bea (ORCID: https://orcid.org/0000-0002-9868-1574)
- Scott R. Evans
- Tara Sanft
- Joanne W. Elena
- Martin R Weiser
Institutions
- Pennington Biomedical Research Center (US)
- Louisiana State University (US)
- Milken Institute (US)
- Pennsylvania State University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Kaiser Permanente (US)
- The University of Texas MD Anderson Cancer Center (US)
- Harvard University (US)
- University of Arizona (US)
- University of Miami (US)
- University of Pittsburgh (US)
- George Washington University (US)
- Cornell University (US)
- Arizona Science Center (US)
- Yale Cancer Center (US)
- University of Alabama at Birmingham (US)
- Yale University (US)
- University of California San Diego (US)
- Energetics (United States) (US)
- Dana-Farber Cancer Institute (US)
- UPMC Hillman Cancer Center (US)
- Human Longevity (United States) (US)
- National Cancer Institute (US)
- Department of Public Health (MM)
- Sylvester Comprehensive Cancer Center (US)
- University of Arizona Cancer Center
- Case Comprehensive Cancer Center
- Case Western Reserve University (US)
- Penn State Milton S. Hershey Medical Center (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2024-08-08
- DOI
- https://doi.org/10.1093/jnci/djae177
- Citations
- 24
- Primary Topic
- Cancer survivorship and care
- Type
- article
- Field-Weighted Citation Impact
- 6.78
Funders
- Memorial Sloan-Kettering Cancer Center
- National Institutes of Health
- National Cancer Institute