Increased neutrophil extracellular trap formation in oligoarticular, polyarticular juvenile idiopathic arthritis and enthesitis-related arthritis: biomarkers for diagnosis and disease activity
Our data suggest that NETs might play pathogenic roles and may be involved in TNF-α-mediated inflammation in JIA. Circulating NET-derived products possess potential diagnostic and disease monitoring value. Furthermore, the preliminary results related to the molecular mechanisms of NET formation in JIA patients provide a theoretical basis for NET-targeted therapy.
Authors
- Yali Wu (ORCID: https://orcid.org/0000-0002-9737-6439)
- Ting Fei Xi
- Shanshan Yang (ORCID: https://orcid.org/0000-0003-4168-3496)
- Yini Wen
- Runming Jin (ORCID: https://orcid.org/0000-0002-7233-0354)
- Yi Liu (ORCID: https://orcid.org/0000-0002-9234-5457)
- Fan Liu (ORCID: https://orcid.org/0000-0002-9481-0797)
- Yucheng Zhong (ORCID: https://orcid.org/0000-0003-4652-4718)
- Ting He (ORCID: https://orcid.org/0000-0002-2856-9501)
- Hongxia Tang (ORCID: https://orcid.org/0000-0003-3386-1854)
- Yanmei Huang (ORCID: https://orcid.org/0000-0001-5075-9654)
- Runji Xiong
- Jing Chen (ORCID: https://orcid.org/0000-0003-0676-1794)
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-09
- DOI
- https://doi.org/10.3389/fimmu.2024.1436193
- Citations
- 6
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.44