Dietary galactose exacerbates autoimmune neuroinflammation via advanced glycation end product-mediated neurodegeneration
These results imply that galactose-induced oligodendrocyte and myelin damage during neuroinflammation may be mediated by AGEs, thereby identifying galactose and its reactive products as potential dietary risk factors for neuroinflammatory diseases such as MS.
Authors
- Aiden Haghikia (ORCID: https://orcid.org/0000-0001-9629-3298)
- De-Hyung Lee
- Barbara Gisevius (ORCID: https://orcid.org/0000-0002-6018-4441)
- Sarah Hirschberg
- Ralf Gold (ORCID: https://orcid.org/0000-0002-7223-3052)
- Stefanie Küerten (ORCID: https://orcid.org/0000-0001-6119-605X)
- Stefanie Haase (ORCID: https://orcid.org/0000-0002-9371-4314)
- Kristina Kuhbandner
- Ralf A. Linker (ORCID: https://orcid.org/0000-0002-8740-3106)
- Florian Mühleck
- D. Freudenstein (ORCID: https://orcid.org/0009-0003-6641-9568)
Institutions
- University of Bonn (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University Hospital Bonn (DE)
- University Hospital Regensburg (DE)
- Universitätsklinikum Erlangen (DE)
- University Hospital Magdeburg (DE)
- St. Josef-Hospital (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-09
- DOI
- https://doi.org/10.3389/fimmu.2024.1367819
- Citations
- 4
- Primary Topic
- Antioxidants, Aging, Portulaca oleracea
- Type
- article
- Field-Weighted Citation Impact
- 1.07