Deciphering the mediating role of CXCL10 in hypothyroidism-induced idiopathic pulmonary fibrosis in European ancestry: a Mendelian randomization study
The findings suggest that hypothyroidism, through altered plasma protein expression, particularly CXCL10, may contribute to the pathogenesis of IPF. This novel insight highlights the potential of CXCL10 as a therapeutic target in IPF, especially in patients with hypothyroidism. The study emphasizes the need for further research into the complex interplay between autoimmune disorders and IPF, with a view towards developing targeted interventions for IPF management.
Authors
- Song Cai (ORCID: https://orcid.org/0000-0003-1482-1291)
- Cong Zhao (ORCID: https://orcid.org/0000-0002-2354-425X)
- Lishan Zhang (ORCID: https://orcid.org/0000-0002-0014-4026)
- Mao Huang (ORCID: https://orcid.org/0000-0002-8912-8072)
- Fang Sun
- Xiaoming Xing
- Jing Zhang (ORCID: https://orcid.org/0000-0002-7650-4702)
- Jing Wang (ORCID: https://orcid.org/0000-0001-7431-8925)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-09
- DOI
- https://doi.org/10.3389/fimmu.2024.1379480
- Citations
- 4
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Natural Science Foundation of China