Integrating network pharmacology, molecular docking and experimental verification to reveal the mechanism of artesunate in inhibiting choroidal melanoma
This study, making the initial exploration, illustrated through network pharmacology combined with molecular docking and <i>in vitro</i>/<i>in vivo</i> assays, confirmed that ART exerted potential anti-cancer effects on CM by promoting apoptosis, inducing cell cycle arrest and increasing intracellular levels of ROS. These findings suggested that ART held significant therapeutic potential for CM.
Authors
- Qingyue Ma
- Wenjuan Luo (ORCID: https://orcid.org/0000-0002-3643-1908)
- Qian Zhang (ORCID: https://orcid.org/0000-0001-5360-5028)
- Xintong Zhao (ORCID: https://orcid.org/0000-0002-9892-6922)
- Haowen Wang (ORCID: https://orcid.org/0009-0003-7994-0547)
- Ke Lei (ORCID: https://orcid.org/0000-0002-2523-5530)
- Ying Sun
- Wen-dan Yi
- Xiaodi Gao
- Yichong Liu (ORCID: https://orcid.org/0000-0002-6423-3706)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-09
- DOI
- https://doi.org/10.3389/fphar.2024.1448381
- Citations
- 10
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.61
Funders
- National Natural Science Foundation of China