Characteristics and impact of infiltration of B-cells from systemic sclerosis patients in a 3D healthy skin model
B-cells and 3D skin cocultures allowed the modelization of B-cells infiltration in tissues observed in SSc, uncovering an influence of the underlying disease and the activation state of B-cells. We showed a pro-inflammatory effect on skin fibroblasts and pro-activation effect on infiltrating B-cells during coculture. This reinforces the role of B-cells in SSc and provide potential targets for future therapeutic approach in this disease.
Authors
- Thomas Guerrier (ORCID: https://orcid.org/0000-0001-8232-9405)
- Alexis Largy (ORCID: https://orcid.org/0000-0001-6193-2459)
- Antonino Bongiovanni (ORCID: https://orcid.org/0000-0001-9876-2940)
- David Launay (ORCID: https://orcid.org/0000-0003-1840-1817)
- Meryem Tardivel (ORCID: https://orcid.org/0000-0002-9907-870X)
- Myriam Simon
- Amélie Bonnefond (ORCID: https://orcid.org/0000-0001-9976-3005)
- Jean‐Pascal Meneboo
- Shéhérazade Sebda
- Blanche Daunou
- Céline Villenet
- Manel Jendoubi (ORCID: https://orcid.org/0000-0002-1047-1274)
- A Collet (ORCID: https://orcid.org/0000-0002-8279-1912)
- Bénédicte Toussaint
- Mehdi Derhourhi (ORCID: https://orcid.org/0000-0001-5020-5379)
- Sylvain Dubucquoi (ORCID: https://orcid.org/0000-0002-8962-3719)
- Mathilde Le Maître
- Martin Figeac (ORCID: https://orcid.org/0000-0001-8523-3708)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Lille (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Lille Inflammation Research International Center (FR)
- Hôpital Claude Huriez (FR)
- Institut de Biologie de Lille (FR)
- European Genomic Institute for Diabetes (FR)
- Institute for Translational Research in Inflammation (FR)
- (Epi)génomique fonctionnelle métabolique et des dysfonctions dans le diabète de type 2 et des maladies associées (FR)
- Imperial College London (GB)
- Université Lille Nord de France (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-08-09
- DOI
- https://doi.org/10.3389/fimmu.2024.1373464
- Citations
- 7
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.97
Funders
- Centre hospitalier régional universitaire de Lille