Associations between fatigue impact and physical and neurobehavioural factors: An exploration in people with progressive multiple sclerosis
The sample comprised 308 pwPMS (62 % female, 27 % primary progressive, 73 % secondary progressive), mean age 52.5 ± 7.2 yrs, median EDSS score 6.0 (4.5-6.5), mean MFIS<sub>Total</sub> 44.1 ± 17.1, with 67.2 % categorised as fatigued. Fatigued participants walked shorter distances (6MWT, p = 0.043), had worse MSWS-12 scores (p < 0.001), and lower average % in MVPA (p = 0.026). The magnitude of associations was mostly weak between MFIS<sub>Total</sub> and physical measures (r = 0.13 to 0.18), apart from the MSWS-12 where it was strong (r = 0.51). The magnitude of correlations were strong between the MFIS<sub>Total</sub> and neurobehavioural measures of anxiety (r = 0.56), depression (r = 0.59), and measures of disease impact (MSIS-physical r = 0.67; MSIS-mental r = 0.71). This pattern was broadly similar for the MSIF subscales. The multivariable model indicated a five-point increase in MSWS-12 was associated with a 14 % increase in the odds of being fatigued (OR [95 %CI]: 1.14 [1.07-1.22], p < 0.0001) CONCLUSION: Management of fatigue should consider both physical and neurobehavioural factors, in cognitively impaired persons with progressive MS.
Authors
- Massimo Filippi (ORCID: https://orcid.org/0000-0002-5485-0479)
- Anthony Feinstein (ORCID: https://orcid.org/0000-0002-0132-0909)
- Jeremy Chataway (ORCID: https://orcid.org/0000-0001-7286-6901)
- Giampaolo Brichetto (ORCID: https://orcid.org/0000-0003-2026-3572)
- Cecilia Meza (ORCID: https://orcid.org/0009-0002-8553-0440)
- Rachel Farrell (ORCID: https://orcid.org/0000-0002-2767-3382)
- Amber Salter (ORCID: https://orcid.org/0000-0002-1088-110X)
- Gary Cutter (ORCID: https://orcid.org/0000-0002-8455-980X)
- RW Motl
- Maria Pia Amato (ORCID: https://orcid.org/0000-0003-3325-3760)
- N D Chiaravalloti
- Peter Feys (ORCID: https://orcid.org/0000-0002-5680-5495)
- John DeLuca (ORCID: https://orcid.org/0000-0003-3745-4156)
- Matilde Inglese (ORCID: https://orcid.org/0000-0002-9610-0297)
- Ulrik Dalgas (ORCID: https://orcid.org/0000-0003-4132-2789)
- Brian M. Sandroff (ORCID: https://orcid.org/0000-0002-2013-7632)
- S. Chatfield
- Luke Connolly (ORCID: https://orcid.org/0000-0002-4471-756X)
- Maria Assunta Rocca (ORCID: https://orcid.org/0000-0003-2358-4320)
- Jennifer A. Freeman (ORCID: https://orcid.org/0000-0002-4072-9758)
- Nick Moore
Institutions
- Sunnybrook Health Science Centre (CA)
- Vita-Salute San Raffaele University (IT)
- University of Toronto (CA)
- Aarhus University (DK)
- Kessler Foundation (US)
- Multiple Sclerosis Foundation (US)
- Health Sciences Centre (CA)
- San Raffaele University of Rome (IT)
- University of Alabama at Birmingham (US)
- University of Illinois Chicago (US)
- Associazione Italiana Sclerosi Multipla (IT)
- Don Carlo Gnocchi Foundation (IT)
- IRCCS Ospedale San Raffaele (IT)
- Ospedale Policlinico San Martino (IT)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- The University of Texas Southwestern Medical Center (US)
- Hasselt University (BE)
- University of Plymouth (GB)
Publication Details
- Journal
- Multiple Sclerosis and Related Disorders
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1016/j.msard.2024.105798
- Citations
- 1
- Primary Topic
- Effects of Vibration on Health
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- Multiple Sclerosis Society of Canada