Phosphoenolpyruvate carboxykinase 2-mediated metabolism promotes lung tumorigenesis by inhibiting mitochondrial-associated apoptotic cell death
In summary, PCK2-mediated metabolism is an important metabolic adaptation for NSCLC cells to acquire resistance to apoptosis under glucose deprivation.
Authors
- Huan Qin (ORCID: https://orcid.org/0000-0002-2398-8758)
- Wenyu Zhang (ORCID: https://orcid.org/0009-0002-3309-9900)
- Ailan Cheng (ORCID: https://orcid.org/0000-0002-4794-4637)
- Feilong Wang (ORCID: https://orcid.org/0000-0002-8100-3670)
- Dongmei Liu
- Qiang Li (ORCID: https://orcid.org/0000-0002-7502-6606)
- Song Zhang (ORCID: https://orcid.org/0000-0002-7726-8326)
- Jing Zhang (ORCID: https://orcid.org/0009-0003-8777-8754)
- Wenjuan He
Institutions
- Tongji University (CN)
- Mayo Clinic in Arizona (US)
- Shanghai East Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-08-09
- DOI
- https://doi.org/10.3389/fphar.2024.1434988
- Citations
- 9
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality