Age-related patterns of microbial dysbiosis in multiplex inflammatory bowel disease families
These findings support that dysbiosis exists as a pre-disease state detectable by faecal and serum biomarkers for IBD risk prediction. Given the expansion of disease-modifying agents and non-invasive imaging, the indices developed here may facilitate earlier diagnoses and improved management in at-risk individuals.
Authors
- Julianne C. Yang (ORCID: https://orcid.org/0000-0001-5898-7221)
- Philip Debbas (ORCID: https://orcid.org/0000-0002-7220-2117)
- Judy H. Cho (ORCID: https://orcid.org/0000-0002-7959-0466)
- Jean‐Frédéric Colombel (ORCID: https://orcid.org/0000-0001-6472-249X)
- Pamela Reyes-Mercedes
- Drew Helmus (ORCID: https://orcid.org/0000-0001-6799-3674)
- Marla C. Dubinsky (ORCID: https://orcid.org/0000-0003-4968-5795)
- Kyle Gettler
- Jonathan P. Jacobs (ORCID: https://orcid.org/0000-0003-4698-0254)
- Graham J. Britton
- Jeremiah J. Faith (ORCID: https://orcid.org/0000-0002-2691-4500)
- Inga Peter
- Esi Lamousé‐Smith (ORCID: https://orcid.org/0000-0002-1067-5795)
- Jianzhong Hu (ORCID: https://orcid.org/0000-0001-8546-5111)
- Joana Torres (ORCID: https://orcid.org/0000-0003-2895-5821)
- Jan Wehkamp (ORCID: https://orcid.org/0000-0001-6788-841X)
- Venu Lagishetty (ORCID: https://orcid.org/0000-0001-6500-8255)
- Gerold Bongers (ORCID: https://orcid.org/0000-0002-3187-120X)
- Elizabeth A. Spencer (ORCID: https://orcid.org/0000-0002-6787-1164)
- Amy Hart
- Jonathan Braun
- Carol J. Landers
Institutions
- Cedars-Sinai Medical Center (US)
- University of California, Los Angeles (US)
- Hospital da Luz (PT)
- Olive View-UCLA Medical Center (US)
- Janssen (United States) (US)
- VA Greater Los Angeles Healthcare System (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Gut
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1136/gutjnl-2024-332475
- Citations
- 10
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- U.S. Department of Veterans Affairs
- Crohn's and Colitis Foundation
- Georgia Clinical and Translational Science Alliance
- National Institute of Diabetes and Digestive and Kidney Diseases
- Janssen Research and Development
- National Center for Advancing Translational Sciences