Association of Epstein-Barr virus (EBV) with nasopharyngeal carcinoma: Experience from a North Indian tertiary care hospital
EBV DNA as an indicator towards NPC among clinically suspected cases had a sensitivity of 60 % and specificity of 87.5 %. In this study, addition of EBV DNA detection by PCR from FFPE tissue sections could confirm EBV association in 20 % of cases where it was not detected by EBV LMP1 IHC, thus helped in increasing the detection of EBV positivity in NPC cases. Early diagnosis of NPC will improve the cure rate and hence reduce the morbidity and mortality rates.
Authors
- Lalit Dar (ORCID: https://orcid.org/0000-0002-9228-1799)
- Raja Pramanik (ORCID: https://orcid.org/0000-0003-0483-6254)
- Debasish Biswal (ORCID: https://orcid.org/0000-0003-3119-359X)
- Megha Brijwal (ORCID: https://orcid.org/0000-0003-4907-7036)
- Alok Thakar (ORCID: https://orcid.org/0000-0002-5691-8932)
- Aanchal Kakkar
- Aashish Choudhary (ORCID: https://orcid.org/0000-0001-8910-1745)
Institutions
- Asian Institute of Medical Sciences (IN)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- Indian Journal of Medical Microbiology
- Published
- 2024-08-09
- DOI
- https://doi.org/10.1016/j.ijmmb.2024.100699
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00