Pseudobulk with proper offsets has the same statistical properties as generalized linear mixed models in single-cell case-control studies
Offset pseudobulk can be easily implemented in any generalized linear model software by tweaking a few options. The codes can be found at https://github.com/hanbin973/pseudobulk_is_mm.
Authors
- Hanbin Lee (ORCID: https://orcid.org/0000-0002-4545-0027)
- Buhm Han (ORCID: https://orcid.org/0000-0002-2266-5164)
Institutions
- Seoul National University (KR)
- University of Michigan (US)
Publication Details
- Journal
- Bioinformatics
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1093/bioinformatics/btae498
- Citations
- 8
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Research Foundation
- Seoul National University
- National Research Foundation of Korea