Advancements in the study of human metagenomic variations: implications for disease development and personalized medicine

<p indent="0mm">Gut microbiome significantly influences human health. Previous studies have examined these relationships at the genus or species level. However, this level of resolution may not be sufficient to fully understand the relationships between the gut microbiome and human health. Microbiome has a wide range of genetic variations, including single nucleotide variants (SNVs) or single-nucleotide polymorphisms (SNP), structural variants (SVs) and mobile genetic elements, which in turn affects microbe-host interactions. In this paper, we first proposed the concept of pharmacometagenomics, and systematically reviewed the impact of human metagenomic variations on host physiological regulation, disease progression and response to individual drug therapy to understand the complex relationships between gut microbes and human health. It will provide a reference for studying the impact of pharmacometagenomics on human health, and a basis for exploring personalized medicine based on gut microbiome.