Replication, safety and immunogenicity of the vectored Ebola vaccine rVSV-ΔG-ZEBOV-GP in a sub-Saharan African paediatric population: A randomised controlled, open-label trial in children aged 1-12 years living in Lambaréné, Gabon
The replication and shedding do not affect the favourable risk-benefit balance of the rVSVΔG-ZEBOV-GP in children.
Authors
- Donata Medaglini (ORCID: https://orcid.org/0000-0003-1729-7325)
- Sylvia Rothenberger (ORCID: https://orcid.org/0000-0001-8633-2994)
- Kossiwa Kokou (ORCID: https://orcid.org/0000-0002-0621-5710)
- Helder I. Nakaya (ORCID: https://orcid.org/0000-0001-5297-9108)
- Claire‐Anne Siegrist (ORCID: https://orcid.org/0000-0001-7984-8669)
- Anita Lumeka Kabwende
- Peter G. Kremsner (ORCID: https://orcid.org/0000-0002-3926-4113)
- Ali M. Harandi
- Ayodele Kamal ALABI (ORCID: https://orcid.org/0000-0002-2121-6631)
- Thirumalaisamy P. Velavan (ORCID: https://orcid.org/0000-0002-9809-9883)
- Ranmali Kavishna (ORCID: https://orcid.org/0000-0002-0066-8727)
- Olivier Engler (ORCID: https://orcid.org/0000-0002-8404-1496)
- Sélidji Todagbé Agnandji (ORCID: https://orcid.org/0000-0003-4693-4207)
- Saïdou Mahmoudou (ORCID: https://orcid.org/0009-0007-6476-4068)
- Fungai P. Musangomunei
- Bisola F. Olubiyi (ORCID: https://orcid.org/0000-0003-2184-0060)
- Juste C. Bie-Ondo
- Sravya Sowdamini Nakka
Institutions
- University of Siena (IT)
- University of British Columbia (CA)
- Duy Tan University (VN)
- Leiden University Medical Center (NL)
- Hospital Israelita Albert Einstein (BR)
- Spiez Laboratory (CH)
- Universitätsklinikum Tübingen (DE)
- Centre de Recherche Médicales de Lambaréné (GA)
- University Hospital Münster (DE)
- University Hospital of Geneva (CH)
- Vietnamese - German Center of Excellence in Medical Research (VN)
- BC Children's Hospital (CA)
- University of Gothenburg (SE)
- University of Lausanne (CH)
Publication Details
- Journal
- Journal of Infection
- Published
- 2024-08-08
- DOI
- https://doi.org/10.1016/j.jinf.2024.106237
- Citations
- 5
- Primary Topic
- Viral Infections and Outbreaks Research
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- Innovative Health Initiative
- Göteborgs Universitet
- Innovative Medicines Initiative
- European and Developing Countries Clinical Trials Partnership