Exploring the action mechanism and effective components of Yupingfeng powder on influenza based on computational system pharmacology and metabolomics
YPF against influenza has multi-target and multi-pathway effects, and the underlying mechanisms may be related to metabolism. The pharmacodynamic effects of core components such as wogonin and isoimperaporin on influenza prevention and treatment were confirmed, which represent promising functional candidates for subsequent influenza prevention and treatment, and provide references for the pharmacological and mechanistic analyses of subsequent formulas.
Authors
- Yaorong Chen
- Youhua Xu (ORCID: https://orcid.org/0000-0002-3258-013X)
- Zifeng Yang (ORCID: https://orcid.org/0000-0002-2681-4171)
- Luping Lin (ORCID: https://orcid.org/0009-0005-5263-1052)
- Ruifeng Chen (ORCID: https://orcid.org/0000-0002-6123-9205)
- Pei Feng (ORCID: https://orcid.org/0000-0003-0400-2110)
- Kexin Wang (ORCID: https://orcid.org/0000-0002-8541-7512)
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-5176-2668)
- Ya Liu (ORCID: https://orcid.org/0009-0001-9447-0892)
- Runfeng Li
- Xiao Wu (ORCID: https://orcid.org/0000-0003-4143-2881)
Institutions
- Macau University of Science and Technology (MO)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Eighth People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-08-08
- DOI
- https://doi.org/10.1016/j.jep.2024.118678
- Citations
- 2
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.47