The IGF2BP3/Notch/Jag1 pathway: A key regulator of hepatic stellate cell ferroptosis in liver fibrosis
IGF2BP3 deficiency inactivates Jag1 signalling. IGF2BP3 deficiency-mediated m<sup>6</sup>A modifications promote HSC ferroptosis. IGF2BP3 inhibition facilitates ferroptosis in HSCs via the Hes1/GPX4 axis. IGF2BP3 deficiency inactivates Jag1/Notch1/3/Hes1 signalling pathway inactivation, leading to the decrease in GPX4, which contributes to HSC ferroptosis.
Authors
- Jianjian Zheng (ORCID: https://orcid.org/0000-0001-8770-4219)
- Weizhi Zhang (ORCID: https://orcid.org/0000-0002-9131-3234)
- Lingling Wu (ORCID: https://orcid.org/0000-0003-3781-3649)
- Lifan Lin
- Han Zeng (ORCID: https://orcid.org/0000-0001-6486-2038)
- Yifei Li (ORCID: https://orcid.org/0000-0002-3096-4287)
- Feng Jiang (ORCID: https://orcid.org/0000-0002-3156-1578)
- Xinmiao Li (ORCID: https://orcid.org/0000-0002-0411-0608)
- Yining Wang
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-08-01
- DOI
- https://doi.org/10.1002/ctm2.1793
- Citations
- 21
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.91
Funders
- National Natural Science Foundation of China
- Wenzhou Municipal Science and Technology Bureau